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Painted in 1886 during the celebrated Dutch master's time studying anatomy at the Antwerp Academy, this provocative early work features a profile view of a human skeleton casually smoking a lit cigarette, rendered in van Gogh's expressive brushwork against a deep shadowy background

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The message from this research is that women should quit smoking before becoming pregnant, or very early on, to reduce the chance of having a baby with a serious and lifelong physical defect", added Hackshaw

"Conventional approaches to reduce the smoking rate have proven to be effective, and we don't need these new products to help bring numbers down further." Vaping could also draw people who have never smoked and once used to it, they may move on to traditional cigarettes, Ho said