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Auerbach O, Stout AP, Hammond ED, Garfinkel L

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We believe that the sensitization-homeostasis model (159161), which highlights the concept that nicotine's dependence liability derives from its ability to stimulate neural pathways responsible for the suppression of craving and due to sensitization, will provide a theoretical framework for addressing the potential role of microglial homeostasis in withdrawal, tolerance and abstinence-related neural adaptations in nicotine addiction in both adults and adolescents

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