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Studies have shown that ACSL4-enriched exosomes can be phagocytosed by microglia, leading to the activation of the nuclear factor kappa-B (NF-B) signaling pathway and polarization of microglia toward a proinflammatory M1 phenotype, thereby amplifying neuroinflammation (He et al., 2024)

15 g of the construct was subsequently transfected into low-passage INS-1E cells using Lipofectamine 3000 (ThermoFisher Scientific) according to manufacturer instructions

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Smoking and drinking Tobacco products contain harmful chemicals and toxins that can damage the lips and mouth