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ETHICAL APPROVAL AND INFORMED CONSENT All participants provided electronic informed consent and UK Biobank received ethical approval from the North-West Multi-center Research Ethics Committee (MREC) covering the whole of UK

When tobacco lies in the mouth between the cheek, gum and teeth, the sweetener encourages bacterial growth, which leads to tooth decay

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For more information on the STAKE Act definition of tobacco products, see the CDPH's website and their publication What is a Tobacco Product under California Law? Notes Under the Stop Tobacco Access to Kids Enforcement (STAKE) Act, Business and Professions Code section 22950.5 amended the definition of a tobacco product effective June 9, 2016