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In replica 1, the extra hydrogen bonds in C23pAcF were found to be distributed throughout various regions of the protein, which would contribute to the increased stability observed (Fig

Widely used GLP-1based medications such as Ozempic and Mounjaroprimarily for Type 2 Diabetes and weight lossare now being explored for broader therapeutic applications

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As alluded to earlier, the effects of GLP-1RAs have been studied in animal studies of neuronal damage involving acute CNS injury (stroke, traumatic brain injury), sub-acute toxin induced dopaminergic loss and prolonged effects of proteopathic stress (e.g., transgenic models of A amyloidosis/tau aggregation) [22,38]