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this, in turn, resulted in the upregulated expression of telomere repeat-binding factor 1/2 (TRF1/TRF2) proteins and strict dependence on p53/p21 signaling, followed by irreversible G2/M cell cycle arrest, ultimately leading to apoptosis

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A multimodal approach that combines surgical and medical approaches towards improving health through the selection of the appropriate treatment and achievement of individualised WL targets should be the standard of care in obesity [14]