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Cell Death & Differentiation 13 , 16631674 (2006)
In regenerative medicine, peptides can promote cell growth, stimulate collagen production, reduce inflammation, and enhance wound healing
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What this tail actually does in practice Initial binding to the cell surface via electrostatic interactions Internalization through a mixture of: direct translocation (rare but possible with strong polyArg motifs) endocytosis (the dominant route for most CPPs) Partial endosomal escape PolyArg motifs can destabilize endosomal membranes, but escape efficiency varies widely
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