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20 , 21 , 22 However, the decline in these exposures, as well as any changes in the prevalence of potentially predisposing inherited genetic variations, 23 , 24 are unlikely to explain a significant fraction of the 61% and 38% declines in lung cancer mortality rates in men (since 1991) and women (since 2002) in the United States, respectively

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The illicit trade is a red herring Tobacco companies have a history of opposing tobacco control measures on the basis that they will increase illicit trade standardised packaging is not unique in this respect