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Metabolic characterization of imatinib-resistant BCR-ABL T315I chronic myeloid leukemia cells indicates down-regulation of glycolytic pathway and low ROS production

In certain embodiments, methods as described herein may be used to improve, in particular, one or more behavioural traits in a subject which are assessed by one or more of the behavioural assessments in Table 2 for which an improvement was identified

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Because metabolic syndrome is often related to obesity, glucose and lipid metabolism have been extensively researched in obese subjects