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Isoflurane can lead to mitochondrial swelling and vacuolization, MMP decline, and electron transport chain dysfunction in the rat hippocampus, resulting in reduced ATP production, oxidative damage to neurons, and neuronal apoptosis, all of which can ultimately cause POCD [49, 50]

[PubMed Central ID: PMC4930540]

Good patient-centred decision making around the use of dietary supplements requires multidisciplinary care, involving oncologists, integrative medicine providers, clinical pharmacists, dietitians and nursing to monitor and mitigate risk as well as to fully document all supplement uses and be aware how they may interact with conventional therapy (239)

J Clin Invest (2004) 113(1):96105.10.1172/JCI17763 176 JessenNDjurhuusCBJorgensenJOJensenLSMollerNLundSet alEvidence against a role for insulin-signaling proteins PI 3-kinase and Akt in insulin resistance in human skeletal muscle induced by short-term GH infusion