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In detail, AR is imported into and localizes to mitochondria with the help of a genuine 36-amino-acid-long mitochondrial localization signal at the N terminus and impedes mtDNA content, TFAM expression, and the expression, assembly, stability, and activity of oxidative phosphorylation (OXPHOS) (90)

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The Pipeline Takeaway: The next 2436 months will likely introduce two to three new approvals offering superior efficacy, oral delivery options, or much better body composition outcomes

This is also why healthcare providers often recommend a gradual dose titration schedule rather than jumping to a higher dose right away