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We also hypothesize that the rapid increase in e-cigarette use after 2007, especially among teenagers, may partially explain why the increase in ANA prevalence was larger during the latter half of the study years and why the increasing ANA time trend was the most pronounced in teenagers ( The ANA time trends across the three smoking-exposure subgroups (as defined by serum cotinine level) are consistent with our hypothesis

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Food and Drug Administrations (FDA) plans to limit nicotine levels in an effort curb tobacco use and addiction was also a major factor in the companys decision

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