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4.57.5 min, mobile phase B increased to 100% and held for 5.5 min

Practical Application Start with vegetables and protein (stimulates early GLP-1 release) Follow with complex carbohydrates (sustains GLP-1 secretion) End with fruit or small dessert (if desired) Protein: 25-30% of calories Fiber-rich carbohydrates: 40-45% of calories Healthy fats: 25-30% of calories Breakfast: Greek yogurt with berries, ground flaxseed, and almonds Lunch: Grilled salmon over mixed greens with quinoa and olive oil dressing Dinner: Chicken breast with roasted vegetables and sweet potato This macronutrient distribution provides the protein and fiber necessary for GLP-1 stimulation while supporting stable blood sugar levels already within normal range

Semaglutide is FDA-approved and clinically studied for medical weight loss

Small AM, Pournamdari A, Melloni GEM, Scirica BM, Bhatt DL, Raz I, et al