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BDNF binds to the tropomyosin receptor kinase B (TrkB) receptor, promoting neuronal survival and plasticity through the activation of key intracellular signalling cascades, including the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), phospholipase C- (PLC-), and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathways [13,14]

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This study, the first of its kind, examines the effects of GLP-1RAs like semaglutide (Ozempic) and compares them with other widely used antihyperglycemic agents

Before you interpret this as evidence that bupropion hinders tirzepatide effectiveness, consider the confounders