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The average measured toxicant result for each VELO nicotine pouch sample was compared with the average measured toxicant result for the reference cigarette emissions (at ISO Intense smoking regime, ISO 20778:2018 2 )

10.1023/a:1021171129766 102

Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

its kind of the bodys way of saying, Whoa, theres something toxic going on here! So the body may boost testosterone in response to nicotine, but its not necessarily a healthy or lasting increase