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Fenech, 3 suggest that certain polymorphisms in folate pathway genes are associated with the levels of hematochemical markers of one-carbon metabolism, and that certain MDS could have been under conditions of folate restriction and/or increased hcy levels at the time of conception

Worgall, T

They tested these inhibitors in cell and animal models. They reported changes in intracellular nicotinamide-related metabolites and examined the biological effects of NNMT inhibition under experimental conditions. These outcomes have increased scientific interest in NNMT biology

De Koning EJ, Lips P, Heijboer AC, Den Heijer M, Bet PM, Van Schoor NM