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Republicans were mostly opposed to tougher regulation of cigarette companies, in keeping with their pro-business ideology

Discussion The cornerstone of THR is the principle that the harms associated with cigarette smoking, at both the individual and population levels, can be reduced by providing adult smokers with alternatives to cigarettes which deliver nicotine but with lower levels of the harmful chemicals found in cigarette smoke 14,15,16

Some of these nicotine receptors in the brain activate part of the pleasure center, which could be responsible for nicotine's euphoric effects

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