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[170] [171] A 2026 systematic review on ADHD medication tolerance found evidence of tolerance developing to some affective state effects of amphetamine (e.g., positive mood and drug liking) within two weeks of daily use, but little to no evidence of long-term tolerance to its therapeutic or cardiovascular effects

This 22nd issue of the Scientific Update, published in October 2025, highlights the efforts of our safety surveillance team

While traditional cigarettes primarily cause longterm harms like nicotine addiction , popcorn lung , and respiratory issues, e-cigarettes and vaping products carry additional acute risks of explosion , fire , and burn injuries

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