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Although it has been established that NEPs can degrade GLP-1(736)NH 2 and (936)NH 2 in vitro [11, 39, 40], we can now show that this occurs (in vivo) in mice with extreme rapidity and independent of DPP-4, consistent with the recent finding that NEP 24.11 knockout mice have higher plasma levels of GLP-1 [41] and that NEP 24.11 is ubiquitously expressed in endothelial cells [42]

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