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Researchers believe this pathway may contribute to increased energy expenditure and broader metabolic effects, creating the triple-receptor profile that separates retatrutide from earlier GLP-1 and dual-agonist compounds

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These small molecule compounds mainly belong to iridoid glycosides, including geniposide, Shanzhiside methylester (SM), 8-O-acetyl-SM, morroniside, catalpol, genipin methyl ether and so on (18, 21)