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Perlman, I feel like my stomach is caving in on itself

doi: 10.1001/jama.291.7.844 12 YanJYangXWangJCaiHCheXYingLet al

The reality is more nuanced, but also more hopeful than you might expect

ACSL4 is required to inhibit GPX4-induced ferroptosis, while ALOX12 is dispensable, whereas not required in p53-mediated ferroptosis, and therefore p53 promotes ferroptosis through a GPX4-independent pathway