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In 2019 a massive clinical trial found that when combined with expert face-to-face support, people who used e-cigarettes to quit smoking were twice as likely to succeed as people who used other nicotine replacement products, such as patches or gum and a statement last month from Public Health England has stated that E-cigarettes are at least 95% less harmful than traditional cigarettes

Although the study focuses primarily on cigarettes, it noted that the addiction to smokeless tobacco or chew is as strong if not stronger than to cigarettes