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Although it remains to be seen to what extent the effects observed are related to the duration of smoking, in our previous work we have shown that at least the lower fatigue resistance in smokers was not related to the duration of smoking or smoking pack years 19

Additionally, nicotine exposure alters brain regions responsible for stress management, learning, and self-control, exacerbating stress and anxiety and impairing an individuals ability to exercise self-control.

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Many of those patients had severe acute illness: 58% required admission to the ICU, 32% required intubation and mechanical ventilation, and 17% had acute respiratory distress syndrome