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Therefore, if a patient is unable to achieve smoking cessation with appropriate support, the available evidence implies that current smokers with CD should in fact be treated more aggressively with biologic and/or thiopurine therapy in an attempt to mitigate future disease risk, especially future surgeries

Lu Q, Sakhatskyy P, Grinnell K, Newton J, Ortiz M, Wang Y, Sanchez-Esteban J, Harrington EO, Rounds S (2011) Cigarette smoke causes lung vascular barrier dysfunction via oxidative stress-mediated inhibition of rhoa and focal adhesion kinase

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