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The mechanism is thought to involve binding of the peptide C terminus to the receptor extracellular domain, followed by insertion of the peptide N terminus into the pocket formed by the transmembrane helices and extracellular loops, instigating receptor activation and signalling 19

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The Expert Consensus on the Diagnosis and Treatment of Hyperhomocysteinemia sets the diagnostic standard for HHcy at 10 umol/L

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