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The typical course led to the development of the acute respiratory distress syndrome, and approximately one third of patients required mechanical ventilation

Large cohort analyses from the COPDGene cohort also showed that fSAD quantified by CT-PRM was common in subjects who had not yet developed airflow limitation diagnosed by spirometry and was associated with accelerated FEV 1 decline and adverse clinical outcomes during follow-up, which reinforced the value of imaging fSAD in early identification and risk stratification (83)

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