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MR is based on three key assumptions: 1) the genetic variants used as instruments for the exposure must be valid and robustly associated with the exposure, 2) there should be no measured or unmeasured confounding of the association between the genetic instrument and the outcome, and 3) the variants should have no independent effect on the outcome other than through the exposure of interest 17

There are also many apps you can use to help. People who have quit smoking often say they miss having something to do with their mouths and hands

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Nicotine and Tobacco Research 6(Suppl 1):S55-S65