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Currently, seven antiobesity medications are approved by the FDA: Phentermine Orlistat A fixed-dose combination of phentermine and topiramate ER A fixed-dose combination of naltrexone SR and bupropion SR Liraglutide Semaglutide Tirzepatide The choice of which antiobesity pharmacotherapy to initiate must be individualized to the patient taking into consideration their goals, their unique challenges with weight loss, the presence of any co-existing medical conditions, and any contraindications to specific medications or drug-drug interactions

[Updated 2024 Apr 30]