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Patients were to be on a stable combined dose of metformin HCl extended-release or immediate-release (at maximum tolerated dose, with minimum dose for enrollment being 1500 mg) and a sulfonylurea (at maximum tolerated dose, with minimum dose for enrollment being 50% of the maximum recommended dose) for 8 weeks prior to enrollment

Its likely that GLP-1 RAs (or their combinations) will be part of a future MASH therapy regimen, given weight loss is the cornerstone treatment and GLP-1 causes weight loss plus some direct hepatic fat reduction

Seeger, C

Effects of melatonin and 3,5,3-triiodothyronine on the development of rat granulosa cells