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[35] [36] By the mid-17th century, most major civilizations had been introduced to tobacco smoking and, in many cases, had already assimilated it into the native culture, despite some continued attempts on the part of rulers to eliminate the practice with penalties or fines

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THC Side Effects Smoking or consuming THC can cause: Problems with concentration, judgment, and memory Dizziness Breathing problems Fast heart rate Nausea and vomiting Drowsiness Loss of balance Side effects from CBD can include: Nausea Diarrhea Upset stomach Tiredness Lightheadedness Crankiness Low blood pressure CBD can also change the way some medicines work