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Other problems may include the following: Heart palpitations Cardiovascular issues Persistent dizziness Extreme drowsiness High blood pressure Serotonin syndrome Sleep disorders Tight chest and difficulty breathing Extreme restlessness and irritability Severe anxiety Zoloft and Weed for the Treatment of Anxiety or Depression Clinical surveys have revealed that when Zoloft and weed interact, they can induce adverse reactions similar to a Zoloft overdose