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Dry air from a heater, for example, can crack the blood vessels and lead to nosebleeds during the night.

For causal mediation analysis, the directed acyclic graph (Figure 1) depicts the assumed causal relationships between household SHS exposure (exposure), self-reported smoking status, asthma status (mediators), sex, nativity (pre-exposure confounders) and the atopic dermatitis status (outcome)

Examples of cigarette, cigar, pipe tobacco and smokeless tobacco packages showing plain and standardized packaging features under consideration can be found in Appendix A