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The authors reiterated the importance of strategies aimed at dissuading uptake of smoking and reducing tobacco consumption levels

Chronic inflammatory responses happen much later, perhaps through uptake and metabolism (bioactivation) of NNK/nicotine in macrophages (Figure 2)

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Although there is little evidence to indicate that follow-up of patients with OED has any influence on preventing the development of cancer, regular review facilitates early detection of OSCC in the event of malignant transformation, which is associated with less destructive surgical treatment and a significantly improved long-term prognosis