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A significant age group sex interaction was observed, with pomegranate extract reducing plasma TMAO AUC in female participants of premenopausal age and male participants while showing opposite effects in female participants assigned to the Older (postmenopausal age) group

Moreover, some other animal studies have reported a similar effect of riboflavin on SOD ( Reference Liang, Liu and Xu 23 , Reference Hirano, Hamajima and Horiuchi 34 , Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 ) , GPx ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Wang, Mei and Chen 36 ) and catalase ( Reference Tumkiratiwong, Tungtrongchitr and Migasena 35 , Reference Lee, Ye and Jones 37 ) activities

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In that case, the company targeted children for the diabetes drug, even though the FDA had not approved the drug for use in children