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However, small modifications to both the amino group and the methoxy group at position 5 of the benzothiazole core did not result in any significant increase or decrease in binding activity as measured by the CPMG assay, and no reliable LO-NMR K D data could be obtained for the analogues (Supplementary Table 1)

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Through its modulation of this pathway, GPS could potentially influence the transcriptional regulation of genes associated with keratinocyte proliferation and differentiation, facilitating the restoration of epidermal homeostasis and skin barrier function

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