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Edited by Arce Ibarra M, Parra Vzquez MR, Bello Baltazar E, Gomes de Araujo L

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When we simultaneously varied initiation, cessation, and relapse probabilities by 25% in directions to maximally increase or decrease smoking prevalence, life expectancy across the scenarios for people with SPD vary by up to 0.6y, whereas life expectancy vary by up to 0.4y in the other three subpopulations

Intravenous nicotine self-administration also allows for the precise quantification of the amount of nicotine infused by the animal (69), but there are translational limits with this approach as humans typically inhale most nicotine-containing products