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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are an increasingly prescribed class of antihyperglycaemic agents for people with type 2 diabetes owing to their glycaemic efficacy with a low risk of hypoglycaemia (except when used in combination with insulin or a sulfonylurea) and proven cardiovascular, renal and weight loss benefits

5-Amino-1MQs membrane-permeable small-molecule structure produces oral bioavailability in rodent models, distinguishing it from peptide compounds and supporting the oral capsule research format

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Slower gains can still yield big victories if people stay with it