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Why the difference is so big: most of the nicotine in a cigarette is destroyed by the burning, or drifts off in the smoke you do not inhale

Competitive strategies increasingly focus on heated tobacco products, e-cigarettes, and nicotine pouches, as declining cigarette volumes in developed markets push innovation toward reduced-risk alternatives

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In addition to other public health measures, packaging requirements have further decreased the prevalence and uptake of smoking, [2] [3] [4] and have reduced cigarette sales in Australia