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Main analysis for nonfatal myocardial infarction (overall) All 32 studies with a total of 20,945 subjects (9,323 subjects in the nicotine groups and 11,622 subjects in the non-nicotine control groups) met the criteria for inclusion in the meta-analysis

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more than 7 drinks per week or 3 drinks per day for females) or through a positive screen for at-risk drinking (eg, a score of 4 or more for males and a score of 3 or more for females on the AUDIT-C).19 Potential barriers were 22 items (eg, lack of training/guidance, poor knowledge of an intervention, lack of time) rated on a scale from 1 to 4 (1 = not a barrier, 2 = minor barrier, 3 = moderate barrier, 4 = significant barrier)