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Although the epigenetic mechanisms by which benzo[a]pyrene and nicotine-induced alterations can be vertically transmitted has not been resolved, smoking-induced abnormal protamination may cause alterations in the methylation pattern of CpG in the promoter regions of DNA in the offspring of smokers [161]

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Aromas from the wrappers are dominated by a strong campfire note, but I can also pick out notes of sweet barnyard, mint leaves, black pepper, charred meat, light cloves, earth and leather tack

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