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The fact that cigarette smoking became less fashionable among upper-income and middle-income groups lulled the public into believing that the United States was well on its way to ending the enormous toll taken by smoking

By comparing model 1 and model 2, the current study observed a weakening of statistical significance and effect sizes across 11 brain regions when BMI was added, suggesting a possible, but not definitively proven, mediating effect of BMI in the association between the increase in smoking pack years and reduced brain volumes