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Section 1899(d)(1)(B)(ii) of the Act also provides the Secretary with discretion to adjust the historical benchmark by such other factors as the Secretary determines appropriate. Pursuant to this authority, over time we have adopted a variety of methods to adjust the historical benchmark to meet certain policy goals

The pain of TMJ disorder is often described as a constant and dull jaw joint pain that worsens with opening or closing the mouth

This is of particular interest in markets with high use of such products (eg, India, Indonesia, Eastern Mediterranean) where their use presents a significant population health risk

According to the international ESPAD survey, Croatia is also among the countries with particularly high rates of daily smoking among 16-year-olds, with a prevalence of approximately 19 per 100,000 cigarettes a day compared to a European average of approximately 10 per 100,000 cigarettes a day