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If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly

The results are in line with other work which shows that population-level controls of tobacco, such as taxation and advertising bans to reduce consumption and initiation, can profoundly impact health over the longer term for many millions of people

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[1] When sales and imports were placed on hold on November 29, 2021 due to a patent dispute with British American Tobacco, the devices were sold at at least 52 flagship stores in malls, mobile units (sometimes in parking lots of convenience stores) and kiosks, as well as pop-up stores inside convenience stores