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While acknowledging that further studies with shorter periods of preoperative smoking interventions were necessary, due to the difficulty of such a long period of abstinence for many smokers, this study made it very clear that the physicians and care team surrounding a smoking patient could have a significant and meaningful impact

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First, while the TNBS and DSS murine models are widely utilized, they only partially recapitulate the chronicity, heterogeneity, and tissue complexity of human IBD and may not capture all aspects of mucosal immunopathology

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