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Similarly, proteins in the Starch and sucrose metabolism pathway, such as hexokinase ( HK ) and glucan endo-1,3-beta-d-glucosidase ( EGLC ), were also significantly upregulated ( However, under low-temperature stress, 61 proteins in the Ribosome (map03011) pathway, including Small subunit ribosomal protein S10 (RP-S10), Large subunit ribosomal protein L4e ( RPL4 ), Large subunit ribosomal protein L2 ( MRPL2 ), Large subunit ribosomal protein L14 ( MRPL14 ), and Small subunit ribosomal protein S11 ( rpsK ), were downregulated, indicating that chilling injury caused ribosomal instability in tobacco leaves, thereby inhibiting protein synthesis
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Allelic association studies have focused in particular on the alleles of genes that affect alcohol metabolism because, as we have already seen, people with impaired activity of the alcohol-metabolizing enzyme, aldehyde dehydrogenase, have unpleasant reactions when they consume alcohol, and are therefore at significantly lower risk of alcohol dependence
