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Psychoactive drugs like cocaine and amphetamines stimulate the effects of neurotransmitters, according to a 2021 article by da Silva et al., published in the journal Current Opinion in Toxicology , titled Neurotoxicity of psychoactive substances: A mechanistic overview . For instance, cocaine increases the availability of the dopamine neurotransmitter and induces symptoms like feelings of pleasure and being rewarded, increased energy, and enhanced arousal, according to a 2015 article by Vivek Verma published in the journal Clinical Psychopharmacology and Neuroscience , titled Classic Studies on the Interaction of Cocaine and the Dopamine Transporter . Another example of drug impact on the brain is observed when psychoactive substances like alcohol reduce the effects of neurotransmitters