While sub-chronic exposure to PG/nicotine promote nAChR7-dependent increased levels of different cytokines and chemokines in the bronchoalveolar lavage fluid (BALF) such as IL-1, IL-2, IL-9, interferon (IFN), granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemoattractant protein-1 (MCP-1/CCL2) and regulated on activation, normal T cell expressed and secreted (RANTES/CCL5), the enhanced levels of IL-1, IL-5 and TNF were nAChR7 independent
However, several studies financed by the industry show how HTPs reduce exposure and formation of harmful constituents compared to cigarettes
These two approaches serve different formulation goals and operate at different points in the product development process
248 Another meta-analysis compared web-based interventions (with interactivity and tailoring) with more basic or comparison conditions (no intervention, usual care, more basic web-based interventions, or non-web interventions)