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Compared with current smokers, participants who quit smoking for 5 to less than 10 years had an HR of 0.71 for CHD (95% CI, 0.57-0.88), 0.43 for PAD (95% CI, 0.28-0.64) and 0.61 for stroke (95% CI, 0.45-0.82)

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While the levels were too low to allow differential S / R quantitation by chiral GC, especially in the presence of the relatively massive levels of S -nicotine, it is considered likely that the S enantiomer was at least dominant because of original formation by reaction of 6-methyl nicotinic acid in the nicotine formation pathway, or subsequent methylation of S -nicotine