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Therefore, the formation and accumulation of OH leads to cell death [45]

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Neuroinflammation and neurotoxic KP metabolites like QUIN suppress neurogenesis in the adult hippocampus and reduce levels of Brain-Derived Neurotrophic Factor (BDNF), a molecule essential for neuronal survival, growth, and plasticity ( 4 Clinical evidence of the association between IBD and depression The mechanistic link between intestinal inflammation and brain dysfunction is strongly corroborated by a robust body of clinical and epidemiological evidence