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[51] isolated bronchial tissue from patients with and without COPD, isolated and cultured goblet cells and promoted their differentiation and found that SAM-pointed domain-containing ETS transcription factor (SPDEF) and forkhead box protein A2 (FOXA2) had abnormal DNA methylation during goblet cell differentiation

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This phenomenon was reported in previous studies in the difference in the concentration of various types of pollutants in mainstream smoke and discarded cigarette butts 31

Our bodies are a bit more resilient and efficient at clearing out filth, but the cotton demonstration is not far off from what happens to the tissues in our lungs